R&D outcomes depend heavily on a variety of factors, some which are under the direct control of the research facility and team. Good Laboratory and Manufacturing Practices can help decrease variables that may confound results. The FDA has several guidance documents which can aid a lab to establish GLPs. 21 CFR Part 58 lays out GLPs, that when properly followed, can eventually lead to compliant R&D outcomes where quality standards are met.
The facility and all equipment within the facility in which R&D is taking place should be up to code. Additionally, proper training of personnel, good documentation practices and standard operating procedures must also be followed to ensure that R&D has optimal outcomes.